Isfahan University of Medical SciencesDental Research Journal1735-33279320120821Reactive lesions of the oral cavity: A retrospective study on 2068 cases10801080ENNoushinJalayer NaderiNosratollahEshghyarDepartment of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. eshghyar@sina.tums.ac.irHoraEsfehanian20120821Background: Reactive lesions of the oral cavity are non-neoplastic proliferations with verysimilar clinical appearance to benign neoplastic proliferation. This similarity is troublesome in thedifferential diagnosis. The aim of this study was to determine the frequency and distribution oforal cavity reactive lesions.Materials and Methods: The study was a retrospective archive review. The medical recordsof 2068 patients with histopathologic diagnosis of oral cavity reactive lesions were studied. Thepatients’ clinical data were registered and evaluated retrospectively. The obtained frequency ofpatients’ age, gender, and anatomic location were analyzed. Descriptive statistics were used forevaluating the registered data.Results: Peripheral giant cell granuloma was the most prevalent lesion (n=623, 30.12%). This wasfollowed by pyogenic granuloma (n=365, 17.65%), epulis fissuratum (n=327, 15.81%), irritation fibroma(n=288, 13.93%), cemento-ossifying fibroma (n=277, 13.40%), inflammatory fibrous hyperplasia(n=177, 8.56%), and inflammatory papillary hyperplasia (n=11, 0.53%). The age ranged from 2 to85 years, with a mean of 39.56 years. The lesions were more common in males (n=1219, 58.95%)than in females (n=849, 41.05%). Attached gingiva with 1331 (64.36%) cases was the most frequentplace of reactive lesions.Conclusion: Peripheral giant cell granuloma was the most prevalent reactive lesion of the oral cavity.The reactive lesions were more common in males, gingival, and the third decade. Some differenceshave been found between the findings of the present study and previous reports.Key Words: Hyperplastic lesions, oral cavity, reactive lesions