Isfahan University of Medical SciencesDental Research Journal1735-33279320120821Evaluation of serum C-reactive protein levels in subjects with aggressive and chronic periodontitis and comparison with healthy controls10821082ENArunaKanaparthyConservative Dentistry, Bapuji Dental College and Hospital, Davangere, Karnataka, India. draruna2008@rediffmail.comRosaiahKanaparthyNandiniNiranjan20120821Background: Periodontal subgingival pathogens affect local and systemic immune responses andinitiate an acute phase systemic inflammatory response characterized by the release of C-reactiveproteins (CRPs). This study has been carried out to evaluate the serum concentration of CRPs, whichcan be used as a marker of periodontal disease as well as a risk indicator for cardiovascular diseases.Materials and Methods: In a retrospective study a total number of 45 subjects were selectedfrom the outpatient department of periodontics a mean age of 40 years. Based on the periodontalstatus, the subjects were divided into 3 groups of 15 subjects each. Group I: Control group [withattachment loss (AL) ≤ 2 mm and pocket depth (PD) < 3 mm], Group II: Generalized aggressiveperiodontitis (AL ≤ 5 mm), Group III: chronic periodontitis (AL ≥ 2 mm, PD ≥ 5 mm), which includesmoderate and severe periodontitis. The clinical parameters recorded were plaque index,gingivalindex, bleeding index, probing PD, and clinical attachment levels and scoring was done on 6 surfacesof all teeth. For the CRP assessment, blood samples were collected from subjects at the time ofclinical examination. Analysis of covariance was used for comparison of mean values between thegroups to adjust the ages (P value < 0.05).Results: Overall, the mean CRP levels were high in subjects with generalized aggressive and chronicperiodontitis compared with controls. This was found to be statistically significant. A statisticallysignificant difference (P = 0.012) was found in the CRP level between groups I and II and betweengroups II and III, and between groups I and III.Conclusion: The results of the present study indicated an increase in serum CRP levels in subjectswith generalized aggressive periodontitis and chronic periodontitis as compared with the controls.Key Words: Aggressive periodontitis, chronic periodontitis, C-reactive proteins, serumconcentration