Isfahan University of Medical SciencesDental Research Journal1735-33279320120821Large oral lipoma: Case report and literature review in Iran10971097ENAhmadMotagiAtousaAminzadehOral Pathology, School of Dentistry, Khorasgan (Isfahan) Branch, Islamic Azad University, Isfahan, Iran.. a.aminzadeh@khuisf.ac.irSeyed MRazavi20120821Lipoma is a benign mesenchymal tumor of fat with uncertain pathogenesis. Although the most commonmesenchymal neoplasm in trunk and proximal portions of the extremities, it is rarely seen in the oralcavity. Oral lipomas are clinically soft, smooth-surfaced nodular masses that mostly are less than 3 cmin size. Typically the tumor is asymptomatic unless bitten or become noticeable because of their size.The buccal mucosa and buccal vestibule are the most common intraoral sites and account for 50% ofall cases. Reported here is a relatively large lipoma of buccal mucosa that was treated surgically underlocal anesthesia. In an 18-month postsurgical follow up no complication or recurrence has occurred. Thiscase will also be compared to intraoral lipomas reported in Iranian population. As lipomas are usuallysmaller than 3 cm in diameter, lipoma with the size reported, is of clinical importance. Since the largelipomas are in differential diagnosis with other, even malignant, mesenchymal, or salivary gland tumors.Thus, this case report recommends clinical awareness in diagnosis of large intraoral soft tissue lesions.Key Words: Buccal mucosa, fatty tumor, lipoma, mouth mucosa