Biochemical markers in oral submucous fibrosis: A review and update

Abstract

Oral submucous fibrosis (OSMF) is a potentially malignant oral condition effectively linked

to the causative habit of chewing areca nut. Since its first description in the 1950s, numerous

epidemiological, biochemical, histological, and genetic studies have been reported. While most

studies point out to the cause and effect of areca nut, co-additive factors are also implicated in

the progression and malignant transformation of this condition. Biochemical investigations have

concentrated on outlining such changes in the blood, serum or tissues of these patients and have

given insights on the possible pathogenesis of OSMF. This article attempts to compile details of

biochemical investigations in OSMF and summarize and infer on the findings.

Key Words:Biochemical parameters, immunology, malignant transformation, oral submucous,fibrosis, trace elements