Discordant tooth agenesis and peg-shaped in a pair of monozygotic twins: Clinical and molecular study

Lívia Azeredo Alves Antunes, Erika Calvano Küchler, Marcelo de Castro Costa, Leonardo Santos Antunes, José Mauro Granjeiro


The present report aimed to study an uncommon case of a pair of twins that presented a discordant

dental phenotype. Family investigation, clinical, radiographic examination and molecular analysis were

performed in both girls. Molecular analysis confirmed the monozygosity by deoxyribonucleic acid

chip technology. One twin presented tooth agenesis in left upper lateral incisor and peg-shaped

on the contra lateral side while the other twin had no dental alterations. The dental casts study

employed digital caliper to compare morphological dimensions and showed alteration only in

peg-shaped tooth. In conclusion, this study provide support that one or more mutated gene could

cause discordances in dental phenotype in these monozygotic twins.

Key Words: Dental anomalies, dental development, monozygotic twins, tooth agenesis

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