Periodontal bone regeneration in intrabony defects using osteoconductive bone graft versus combination of osteoconductive and osteostimulative bone graft: A comparative study

Abstract

Background: Bone loss is one of the hallmarks of periodontitis. Hence, a major focus of research into periodontal regeneration has concentrated on the initiation of Osteogenesis. Osteoinduction requires the differentiation of mesenchymal cells into osteoblasts with subsequent formation of new bone. The present study has been carried out to evaluate periodontal bone regeneration in intrabony defects using osteostimulative oleaginous calcium hydroxide suspension Osteora® (Metacura, Germany) in combination with osteoconductive bone graft Ossifi ™ (Equinox Medical Technologies, Holland).

Materials and Methods: A total of 22 sites in patients within the age range of 25-50 years, with intrabony defects were selected and divided into two groups (Group A and Group B) by using the split-mouth design technique. All the selected sites were assessed with the clinical parameters such as - Plaque Index, Gingival Index, Sulcus Bleeding Index, Periodontal Probing Depth, Clinical Attachment Level, Gingival Recession and radiographic parameter to assess the amount of Defect Fill. Mann-Whitey U-test and Wilcoxon Signed Rank Test has been used to fi nd the signifi cance of study parameters on continuous scale for the comparison between the mesial and distal bone levels. P < 0.05 was considered to be statistically signifi cant.

Results: Osteora® in combination with osteoconductive Ossifi ™ showed better regenerative potential and more signifi cant amount of bone fi ll in periodontal intrabony defects than when Ossifi ™ was used alone (P = 0.039).

Conclusion: Osteora® can be used as an adjunct to osteoconductive bone grafts, as an osteostimulating agent in the treatment of periodontal intrabony defects.

Key Words: Bone substitutes, calcium hydroxide, osteogenesis, periodontal bone loss,

periodontal regeneration