Isfahan University of Medical SciencesDental Research Journal1735-33272120080120Evaluation of Serum Immunoglobulins (A, G, M) and Complement Components (C3, C4) in Isfahan dental Clinics Patients with Recurrent Aphthous Stomatitis1717P.Ghalayani. drj@dnt.mui.ac.irB.Khorami20101106Background and aim Recurrent aphthous stomatitis (RAS) is an oral mucous lesion in patients with no other signs of disease. Investigators have always notified the role of immune system especially humoral immunity in aphthous immunopathogenesis.The aim of this case-controlled study was to measure amount of serum immunoglobulins (A, G, M) and complement components (C3, C4) in patients with RAS and to evaluate any relation between differences in these factors and pathogenesis of RAS. Methods and Materials Imunoglobulins (A, G, M) and complement components (C3, C4) of 50 patients with RAS were measured by using single radial immunodiffusion technique (SRID T). The results were compared with immunoglobulins (A, G, M) and complement components (C3, C4) of 50 healthy people whom were similar in age and sex with the patients of case group. Results Results showed that the patients group had higher level of IgA and IgM while serum IgG was similar in both groups. The C3 was lower in aphthous patients while no significant difference waS found in amount of C4. The sex had no significant effect on serum level of measured factors. Discussion The resul.ts show that the humoral immunity reaction has an important role in immunopathogenesis of RAS. This humoral response might accure as a result of cellular immunity reaction. Key words Immunoglobulins - Complement - Aphthous