Therapeutic effects of Zataria Multifl ora essential oil on recurrent oral aphthous lesion

Neda Babaee, Mahmoud Baradaran, Hossein Mohamadi, Shaghayegh Nooribayat


Background: Aphthous lesions are one of the most common diseases of the oral cavity. They can cause

severe pain, and there is no defi nite treatment. The purpose of this study was to determine the effi cacy of

Zataria multifl ora (ZM, a thyme-like plant) essential oil for the control and treatment of aphthous lesions.

Materials and Methods: This Triple blind clinical trial study was performed on 28 patients who

were divided into two groups (eight men and six women in each group) and given ZM or placebo

(control). The healing time, pain intensity, and aphthous zone diameter were recorded for each patient

and followed for 6-month. Data were analyzed using Mann–Whitney and Friedman tests (P < 0.05).

Results: After 6-month of follow-up, 4 patients in the placebo group and 6 patients in the ZM group

suffered from recurrent aphthous lesions. The average complete healing time and duration of burning

sensation were signifi cantly lower in the ZM group (P < 0.05). Signifi cant difference was observed

between the two groups with regard to the diameter of lesions and halo of the lesions (P < 0.05).

Conclusion: Within the limitations of this study, ZM shortened the healing period compared to


Key Words: Aphthous stomatitis, therapeutics, Zataria multifl ora

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