Bispectoral index scores of pediatric patients under dental treatment and recovery conditions: Study of children assigned for general anesthesia under propofol and isofl oran regimes

Abstract

Background: This study was planned to determine the relationship between bispectoral index
(BIS) during dental treatment and recovery conditions in children undergoing two regimes of
anesthesia of propofol and isofl urane.
Materials and Methods: In this single-blind clinical trial study, 57 4-7-year-old healthy children who
had been referred for dental treatment under general anesthesia between 60 and 90 min were selected
by convenience sampling and assigned to two groups, after obtaining their parents’ written consent. The
anesthesia was induced by inhalation. For the fi rst group, the anesthesia was preserved by a mixture of
oxygen (50%), nitrous oxide (50%), and isofl urane (1%). For the second group, the anesthesia was preserved
by a mixture of oxygen (50%), nitrous oxide (50%), and propofol was administered intravenously at a dose of
100 Ng/kg/min. The patients’ vital signs, BIS, and agitation scores were recorded every 10 min. The data were
analyzed by repeated measure ANOVA and t-tests at a signifi cance level of α = 0.05 using SPSS version 20.
Results: The results of independent t-test for anesthesia time showed no statistically signifi cant
difference between isofl urane and propofol (P = 0.87). Controlling age, the BIS difference between
the two anesthetic agents was not signifi cant (P > 0.05); however, it was negatively correlated with
the duration of anesthesia and the discharge time (P = 0.001, r = –0.308) and (P < 0.001, r = –0.55).
Conclusion: The same depth of anesthesia is produced by propofol and isofl urane, but lower
recovery complications from anesthesia are observed with isofl urane.

Key Words: Anesthesia, anxiety, isofl urane, pediatric dentistry, propofol