Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma

Elham Hormozi, Vahid Nourollahi Fard, Mohammad Ali Naseri, Nima Haghighat Jahromi, Forooz Keshani


Background: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT),

is a developmental lesion which should be carefully monitored and it exhibits development

mechanisms and biologic behaviors different from those of other more common lesions such

as dentigerous and radicular cysts. CD10 antigen is a cell surface metalloendopeptidase, which

inactivates various peptides that are physiologically active. Studies have shown that increase in the

expression of CD10 in the stromal cells helps the progression of the tumor. Ameloblastoma (AB)

is a local invasive tumor and given the role of supporting connective tissue stroma in the aggression

and progression. The aim of the present study was to comparatively evaluate the expression of

CD10 in the connective tissue stroma of AB and OKC as a KCOT.

Materials and Methods: In this retrospective, cross‑sectional study, 14 paraffin blocks of KCOT

and 9 of AB (7 multicystic and 2 unicystic) were evaluated with CD10 immunohistochemical

expression in the connective tissue stroma of AB and the connective tissue wall of KCOT. The data

were analyzed with Fisher’s exact test (P < 0.05).

Results: In 8 samples of 9 AB and in 13 samples of 14 KOT lesions, expression of CD10 was

shown. Fisher’s exact test did not reveal any significant differences between these two lesions in

the expression of CD10 (P = 0.64).

Conclusion: The results of this study propose that high expression rate of CD10 might be one

of the reasons for the aggressive behavior of AB and high recurrence rate of OKC and reinforce

the classification of OKC as an odontogenic tumor.

Key Words: Ameloblastoma, CD10, keratocystic, odontogenic tumor, odontogenic keratocyst

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