A comparative evaluation of remineralizing ability of bioactive glass and amorphous calcium phosphate: Casein phosphopeptide on early enamel lesion

Udaya Kumar Palaniswamy, Neha Prashar, Mamta Kaushik, Surender Ram Lakkam, Shikha Arya, Swetha Pebbeti


Background: This study was done to evaluate remineralizing potential of bioactive glasses (BAGs)and amorphous calcium phosphate‑casein phosphopeptide (ACP‑CPP) on early enamel lesion.Materials and Methods: Twenty freshly extracted mandibular premolars were sectioned sagittally.The buccal half was impregnated in acrylic resin blocks and treated with 37% phosphoric acid inliquid form, to demineralize enamel surface to simulate early enamel lesion. The samples were dividedinto two groups. The samples in Group I were treated with ACP‑CPP (GC Tooth Mousse) and inGroup II with BAG (Sensodyne Repair and Protect) and stored in saliva to prevent dehydration.The samples were tested for microhardness.Statistical Analysis: The data obtained was analyzed using ANOVA post hoc multiple comparisonand independent sample t‑test and presented as a mean and standard deviation.Results: All the samples showed a decrease in the microhardness after demineralization.After application of remineralizing agents, Group II showed a highly significant increase in themicrohardness (P < 0.05) after 10 days, while Group I showed a significant increase in microhardnessafter 15 days (P < 0.05).Conclusion: Both the remineralizing agents tested in this study can be considered effective inrepair and prevention of demineralization. BAG showed better results initially, but eventually bothhave similar remineralizing potential.

Key Words:casein phosphopeptide-amorphous calcium phosphate nanocomplex , NovaMin ,enamel,remineralization,hardness, number

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