Comparison of anti‑inflammatory and analgesic effects of Ginger powder and Ibuprofen in postsurgical pain model: A randomized, double‑blind, case–control clinical trial

Farshid Rayati, Fatemeh Hajmanouchehri, Elnaz Najafi


Background: Ginger has been used as an herbal drug for a long time for the treatment of chronic
inflammatory conditions.
Materials and Methods: This randomized, double‑blind clinical trial was conducted on 67 healthy
adults with at least one impacted lower third molar. Participants were randomly allocated into three
groups: Ibuprofen, GingerGinger, and placebo. Evaluation of inflammation was done by measuring
cheek swelling, mouth opening ability, serum C‑reactive protein (CRP) levels, and visual analog
scale (for pain scoring). The number and the time of using rescue medication were recorded too.
Results: Sixty patients completed the study. In all three groups, there was a significant increase in
the mean cheek swelling measures, compared with the baseline, until day 5. The reduction in mouth
opening ability was significant in all three groups, compared with the baseline, until day 5. There was
no significant difference between ibuprofenand ginger groups in pain scores in all follow‑up days.
Number of required rescue medication on the day of surgery was significantly more in the placebo
group. No significant or strong correlations were found between CRP levels and clinical findings.
Conclusion: Within the limitations of this study, it can ban be concluded that gingerpowder is as
effective as ibuprofenin the management of postsurgical sequelae. Furthermore, CRP levels alone
are not suggested for the assessment of anti‑inflammatory effects of drugs.
Key Words: C‑reactive protein, Ginger, Ibuprofen, surgery, third molar

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