Effectiveness of MI Paste Plus and Remin Pro on remineralization and color improvement of postorthodontic white spot lesions

Abstract

Background: This clinical trial investigated the effectiveness of two remineralizing creams on
regression of white spot lesions (WSLs) after orthodontic therapy.
Materials and Methods: The study included patients with WSLs on their upper anterior teeth
who recently completed orthodontic treatment at the Department of Orthodontics of Mashhad
Dental School and two private offices. The participants were randomly assigned into three groups
by treatment: (1) a 12‑week regimen of a cream containing casein phosphopeptide‑amorphous
calcium phosphate and fluoride (MI Paste Plus); (2) a 12‑week regimen of a cream containing
hydroxyapatite and fluoride (Remin Pro); and (3) usual home care (control). Thirty‑nine patients
participated and three withdrew. The main outcomes including area, mineral content, and color of
WSLs were measured at enrolment and 4, 8, and 12 weeks later, respectively. Blinding was applied
for outcome assessment only. The data were analyzed by analysis of variance and repeated measures analysis at the statistical significance of P < 0.05.
Results: Over a 3‑month period, the application of both MI Paste Plus and Remin Pro caused significantly greater reduction in area and significantly higher increase in mineral content of WSLs compared to the control group (P < 0.05). The appearance of WSLs improved significantly in
both experimental groups (P < 0.05), but not in the control group. No side effect was observed
throughout the experiment.
Conclusion: The application of either MI Paste Plus or Remin Pro was effective in reducing the area, increasing the mineral content and improving the appearance of demineralized enam

that these products could be recommended for managing postorthodontic WSLs.

Key Words: Hydroxyapatite, orthodontic treatment, remineralization, white spot