Prevention of secondary caries by a new antibacterial compound

Ali Eskandarizadeh, Iman Mohammadzadeh, Arash Shahravan, Mohammad Bavafa, Sina Kakooei, Molouk Torabi


Background: Since secondary caries is one of the main problems of dental composites. The
creation of an antibacterial property in these composites is essential. The objective of this study
was to synthesize 3‑(2, 5‑dimethylfuran‑3‑yl)‑1H‑pyrazole‑5(4H)‑one and check its biocompatibility
and antibacterial properties in flowable dental composites.
Materials and Methods: In this animal study, the antibacterial activity of flowable resin composites
containing 0–5 wt% 3‑(2,5‑dimethylfuran‑3‑yl)‑1H‑pyrazole‑5(4H)‑one was investigated by using
agar diffusion and direct contact tests on the cured resins. Statistical analysis was performed using
one‑way ANOVA test (P < 0.001). Thirty male albino Wistar rats were used, weighing 200–250 g.
Animals were randomly divided into three groups of ten; each animal received three implants,
3‑(2, 5‑dimethylfuran‑3‑yl)‑1H‑pyrazole‑5(4H)‑one, penicillin V, and an empty polyethylene tube.
A pathologist, without knowing the type of material tested and the timing of the test, examined
the samples. Statistical analysis was performed using Kruskal–Wallis test (P < 0.001).
Results: According to our findings, although the agar diffusion test reveals no significant
difference between the groups, the direct contact test demonstrates that, by increasing the
3‑(2,5‑dimethylfuran‑3‑yl)‑1H‑pyrazole‑5(4H)‑one content, the bacterial growth was significantly
diminished and the 3‑(2,5‑dimethylfuran‑3‑yl)‑1H‑pyrazole‑5(4H)‑one has a good biocompatibility
(P < 0.05).
Conclusion: Incorporation of 3‑(2,5‑dimethylfuran‑3‑yl)‑IH‑pyrazole‑5(4H)‑one into flowable
resin composites can be useful to prevent Streptococcus mutans activity.


Antibacterial agents, dental caries, dental materials, Streptococcus mutans

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