Randomized, controlled clinical trial to evaluate efficacy of sticky bone and concentrated growth factor in the management of intrabony defects: 12 months follow‑up study

Abstract

Background: Platelet derivatives are enriched growth factors that ameliorate various cellular
processes in regeneration. The present clinical trial aimed to evaluate and compare the effects of
sticky bone and concentrated growth factors (CGFs) in the treatment of intrabony osseous defects
by cone‑beam computed tomography (CBCT).
Materials and Methods: The study included 20 patients having 40 intrabony defects. 20 sites
each were included in both test group (Sticky bone) and Control group (CGF alone). The clinical
parameters including probing pocket depth (PPD) and clinical attachment level (CAL) were assessed
at baseline and 6 and 12 months posttherapy. The radiographic parameters including the depth,
mesiodistal (MD), and the buccolingual (BL) width of the defect to assess the amount of bone fill
were examined at baseline and after 12 months using CBCT.
Results: Twelve months posttherapy clinical results indicated a significant reduction of PPD and
gain in CAL in both the study groups. Similar observations were recorded with CBCT radiographic
parameters where the intrabony defect depth and MD defect width for the test group and control
group significantly reduced after 12 months’ posttherapy (P < 0.0001). However, no significant
reduction in BL defect width was observed in control group (P = 0.577) in contrast to the test
group (P = 0.028) after 12 months’ posttherapy.
Conclusion: Intrabony defects treated with sticky bone showed improved clinical and radiographic
parameters indicative of enhanced periodontal regeneration as compared to CGF alone treated sites.
Key Words: Concentrated growth factors, intrabony defects, periodontal regeneration,
periodontitis, sticky bone