Clinical, histological, and histomorphometrical comparison of CenoBone® with and without plasma rich in growth factor for edentulous ridge preservation in the dental sockets

Farshad Keshavarzi, Fateme Ahrari, Maryam Seyedmajidi, Maryam Ziaei, Ali Bijani, Niloofar Jenabian


Background: The aim of this study was to compare the clinical, histological, and histomorphometrical
outcomes of CenoBone® allograft with and without plasma rich in growth factor (PRGF) for the
preservation of edentulous ridge in the dental sockets.
Materials and Methods: This study is experimental clinical trial that 14 dental sockets were
included the sockets required ridge preservation followed by implant placement in the premolar
and molar of the mandible. After extraction of the teeth, the CenoBone® allograft and PRGF were
used in the test group and CenoBone® allograft was used alone in the control group. During the
first stage of surgery and 5 months later, in the second stage of surgery (implant placement), the
vertical changes of the ridge were measured. Furthermore, using Core‑Biopsy in the second stage
of surgery, criteria of histologic and histomorphometric were determined. Data were analyzed
with t‑test, Mann–Whitney U‑test, and Fisher’s exact test at the level of significance of P < 0.05.
Results: The mean trabecular thickness in the test group (52.18 ± 5.53) was significantly higher
than that in the control group (41.53 ± 10.40) (P = 0.344). However, there were no significant
differences in the mean values of vertical bone absorption, bone percentage, remaining biomaterials,
inflammation, and blood vessels between the two groups. There was no case of foreign body reaction
and the bone was vital in all the cases and in direct contact with the biomaterial.
Conclusion: Although CenoBone® allograft with PRGF was effective in some histomorphometric
factors such as trabecular thickness, it did not lead to significant clinical changes.
Key Words: Allografts, dental implants, plasma, socket graft

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