Isfahan University of Medical SciencesDental Research Journal1735-33278220110413Primary Intraosseous Carcinoma of Mandible: A Case Report247247ENKirtyNandimathVenkateshGNaikmasurMedhaBabshetPost-graduate student, Department of Oral Medicine and Radiology, SDM College of Dental Sciences and Hospital, Dharwad, Karnataka, India. medhababshet@hotmail.com20110216Primary de novo intraosseous carcinoma is a rare neoplastic lesion which commonly occurs in the jaws. It is an epithelial odontogenic malignancy arising from odontogenic epithelial residues in the bone rather than from a preexisting epithelial lesion. In the present case report, the clinical, radiological and histological features of primary de novo intraosseous carcinoma are discussed and its aggressiveness and local invasiveness are highlighted. Keywords: Mandible, Primary intraosseous carcinoma, Squamous cell carcinoma.