Efficacy of autologous platelet concentrates for root coverage of Miller’s Class I and II gingival recession defects: A systematic review and meta‑analysis

Abstract

Background: This systematic review and meta‑analysis aimed to assess the efficacy of autologous
platelet concentrate (APCs) in comparison with coronally‑advanced flap alone or in combination
with connective tissue graft or other biomaterials or bioactive agents for root coverage (RC) of
Miller’s Class I and II gingival recession defects by measuring the keratinized mucosa width (KMW).
Materials and Methods: This systematic review and meta‑analysis was conducted in accordance
with the preferred reporting items for systematic reviews and meta‑analysis guidelines. An electronic
search of the literature was conducted in PubMed, EMBASE, Scopus, Cochrane, Web of Science,
Magiran, Scientific Information Database, and Irandoc for randomized clinical trials (RCTs) that
used APCs for RC in their intervention group. Eligible articles were retrieved by assessment of
titles and abstracts and then the full texts. The risk of bias was assessed by the Cochrane Library
Risk of Bias Assessment Tool. Meta‑analysis was carried out by RevMan 5.3 software. In the case of
homogeneity, variables were reported as weighted mean difference (WMD) with 95% confidence
interval (CI) for each group.
Results: The search yielded 689 articles; out of which, 32 were eligible for study inclusion.
Meta‑analysis did not show any additional effect for RC and KMW with APCs. Clinical parameters
were as follows: RC: WMD = −1.57 mm (95% CI: −2.49, −0.659; P = 0.001) and KMW:
−0.106 mm (95% CI: −0.3222, 0.110; P = 0.337).
Conclusion: The application of APCs for RC of Miller’s Class I and II gingival recession defects
does not seem to improve the clinical parameters.
Key Words: Gingival recession, mucogingival surgery, periodontal plastic surgery, platelet‑rich
fibrin, root resorption

Highlight

Fatemeh Yazdanfar: Pubmed,Google Scholar