Comparison of casein phosphopeptide‑amorphous calcium phosphate fluoride paste and a propolis‑containing herbal toothpaste in dentinal hypersensitivity: A randomized trial

Abstract

Background: This study aimed to compare the efficacy of casein phosphopeptide‑amorphous
calcium phosphate fluoride (CPP‑ACPF) and propolis‑based herbal toothpaste in the treatment
of dentin hypersensitivity (DH).
Materials and Methods: In this clinical trial, 20 patients (7 men and 13 women) who met the
inclusion criteria were randomly divided into two groups. One group received the herbal toothpaste
containing propolis (Herbex®), while the other received a paste containing CPP‑ACPF (GC®
MI‑Paste Plus). Two nonadjacent teeth with DH in two quadrants of each patient were assessed.
The pain was determined through the visual analog scale (VAS) in cold and airblast tests before
the intervention (baseline) as well as at 15 min, 1, 2, 4, and 8 weeks after the first application.
Three‑level mixed effect model (repeated measurement, tooth, and patients) was used to analyze
the VAS score data. Estimation of fixed effect parameters with standard error and the intraclass
correlation coefficient that quantifies the degree to which data at the lower level are correlated
were reported. The statistical significance level was determined as P < 0.05.
Results: The mean pain intensity score after 8 weeks significantly decreased in the propolis‑based
toothpaste group (P < 0.001) and CPP‑ACPF paste group (P < 0.001) compared with baseline.
Betweenn‑group comparison in the 8th week showed a significantly lower pain score in the
propolis‑based toothpaste group compared with the CPP‑ACPF‑containing paste (P = 0.02). However,
at other intervals, there were no significant differences between the two groups (P > 0.05).
Conclusion: The use of both herbal toothpaste containing propolis and CPP‑ACPF‑containing
paste for 8 weeks effectively reduced DH, with a higher desensitizing effect experienced in the
former group.
Key Words: Casein phosphopeptide‑amorphous calcium phosphate fluoride, dentin
hypersensitivity, propolis, toothpaste

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Narges Naghsh: Pubmed,Google Scholar