Dentinogenic ghost cell tumor: Two case reports and review of the literature

Abstract

Dentinogenic ghost cell tumor (DGCT) is a rare odontogenic neoplasm, representing a solid
variant of the calcifying odontogenic cyst (COC), accounting for 2%–14% of all COCs and <0.5%
of odontogenic tumors. Its unique histological and clinical characteristics, coupled with its potential
for local invasiveness, underscore the necessity for accurate diagnosis and management. This article
reports two cases of DGCT Case 1involves a 13‑year‑old boy presented with the absence of
permanent teeth 4 and 5. Radiographic examinations revealed a mixed radiolucent–radiopaque lesion
in the left mandible associated with the impacted permanent teeth. The lesion exhibited well‑defined
borders and significant calcifications. Microscopic analysis revealed islands of odontogenic epithelium
with features resembling ameloblasts, numerous ghost cells, and areas of dystrophic calcification,
confirming the diagnosis of DGCT. Case 2 involves A 67‑year‑old male presented with an exophytic
lesion on the left side of the mandibular alveolar mucosa. On pathologic examination, the sample
revealed features that led to the diagnosis of a peripheral DGCT. In the first case, given the lesion’s
size and location, a surgical excision was performed using an intraoral approach under general
anesthesia, including a margin of healthy tissue. Short‑term follow‑ups were conducted every
3 months, and no recurrence was noted after 6 months. In the second case, an excision biopsy and
short‑term follow‑up were conducted. This case highlights the clinical presentation, radiographic
features, and histopathological characteristics of two cases of DGCT, emphasizing the importance
of surgical intervention and regular follow‑up in managing this rare neoplasm. Enhanced awareness
and understanding of DGCT are essential for timely diagnosis and effective treatment, particularly
in pediatric patients presenting with dental abnormalities.
Key Words: Calcifying odontogenic cyst, dentinogenic ghost cell tumor, odontogenic neoplasms

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Nedasadat Mirmohammadsadeghi: Pubmed,Google Scholar