Isfahan University of Medical SciencesDental Research Journal1735-33274220080723Pharmacological Strategies to Control Post-operative Endodontic Pain3333ZahedMohammadiAssistant Professor, Department of Endodontics, School of Dentistry, Sadoughi University of Medical Sciences, Yazd, Iran. mohammadi_zahed@yahoo.comAlirezaFarhadMeisamKhalesi20101106Patients typically associate dental care with pain. Pain has both physiological and psychological components. Endodontic post-treatment pain continues to be a significant problem facing the dental profession. For those patients presenting with preoperative pain, it has been reported that up to 80% of this population will continue to report pain after endodontic treatment. Many studies have demonstrated that endodontic treatment is efficacious in reducing post-treatment pain. Despite the fact that the pain relief afforded by endodontic treatment is effective, it is rarely immediate and complete. Therefore, it is evident that post-treatment analgesic intervention is required in a variable percentage of endodontic cases. The purpose of this review article was to assess three main pharmacologic approaches in the control of post-treatment endodontic pain.Key words: Endodontic treatment, Pain control, Pharmacology