Comparative Evaluation of Metal Ions Release from Titanium and Ti-6Al-7Nb into Bio-Fluids

Lori A Joseph, Omoniyi K Israel, Ekanem J Edet


Background: The study was designed to investigate the effects of pH, chloride ions and nature of some bio-fluids on the amount of metal ions released from titanium and TiAl6Nb7 plates following incubation in actual and simulated bio-fluids over time.

Methods: The amounts of released metal ions from commercially pure titanium (CpTi) and TiAl6Nb7 of surgical grade on immersion in 20 mL Hank's solution of pH 4.0 or 7.0, Hank's solution of high chloride ions concentration, Whole Blood Serum (WBS) and Phosphate Buffered Saline (PBS) at 37oC were determined over an incubation time of 20 weeks using atomic absorption spectrophotometry. The levels of released metal ions were compared by two-way ANOVA and Duncan's post-hoc tests. The amounts of titanium ions released by the samples were analyzed by Pearson's correlation.

Results: TiAl6Nb7 plate showed no release of Ti ions into the test solutions until after 12 weeks of incubation, while Ti ions were released from the CpTi plate from the 1 day immersion time. The release of measurable amount of Al ions from TiAl6Nb7 was after 12 weeks of incubation. The rate of release of Ti and Al ions from the samples increased initially with incubation time and then stabilized due to adsorption-desorption equilibrium.

Conclusion: The results showed that variations in pH and chloride ions of the test media has a significant effect on the amounts of Ti ions released, while increase in chloride ions concentration significantly elevates the release of Al ions into the bio-fluids.

Keywords: Biocompatibility, corrosion, ions, pH, titanium

Full Text:



  • There are currently no refbacks.