Isfahan University of Medical SciencesDental Research Journal1735-33279120120218A four-week solubility assessment of AH-26 and four new root canal sealers892892ENNiloofarAzadiArzhangFallahdoostPaymanMehrvarzfarHamidRakhshanVahidRakhshanDepartment of Dental Anatomy and Morphology, Dental Branch, Islamic Azad University, Tehran, Iran. vahid.rakhshan@gmail.com20120218Background: The strong link between sealer solubility and periapical reinfection indicates thatwater solubility of new sealers should be studied. This study aimed to assess the water solubilityof five root canal sealers (AH-26, Topseal, 2-Seal, Acroseal, and Roeko Seal Automix [RSA]).Materials and Methods: In this in vitro experimental study, 30 specimens were fabricated fromeach of the abovementioned sealants. Then they were weighed and randomly divided into threesubgroups of 10 each (A, B, and C). They were set at 37°C and 100% RH, in accordance with ANSI/ADA 57 and ISO 6876-2001 requirements. Afterward, the specimens in subgroups A were incubatedat 37°C and 100% RH for 24 hours, while the specimens in the subgroups B and C were incubatedin the same conditions for 7 days and 28 days, respectively. After incubation, the specimens weredried with blotting paper and were incubated for 24 hours at 37°C and 0% RH. Then they wereweighed. The percentage of weight loss was regarded as water solubility.Results: The mean solubility of the sealers AH-26, Acroseal, Topseal, 2-Seal, and RSA were 0.28%,0.36%, 0.07%, 0.037%, and 0.141% after 24 hours, respectively. After 28 days, their solubility were1.75%, 0.746%, 0.082%, 0.04%, and 0.517%, respectively. Only the solubility of the sealers 2-Sealand Topseal were not statistically different (P>0.3 [Tukey’s]). Again only the solubility of 2-Seal andTopseal did not significantly increase between the 7th day and the 28th day of incubation (P>0.6[paired-samples t]).Conclusion: All tested materials met the standards (maximum weight loss of 3% within 24 hours).However, the results of 2-Seal followed by Topseal were the most favorable ones.Key Words: Dental materials, endodontics, root canal sealants, solubility, standard