Isfahan University of Medical SciencesDental Research Journal1735-33279120120218Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study898898ENSatyawan G.DamleDepartment of Pediatric Dentistry, Maharishi Markandeshwar University, Mullana, Ambala, India. sgdamle@gmail.comDeoyaniDHiteshwarBhattalRenuYadavAshishLomba20120218Background: The efficacy of fluoridated dentifrices in caries prevention has been well documentedand research into various formulations continues for a more effective dentifrice. This study evaluatedthe anti-caries and anti-plaque efficacy of a dentifrice containing sodium monofluorophosphate(1000 ppm) and calcium glycerophosphate, and compared it with a non-fluoridated dentifrice.Materials and Methods: A total of 595 school children (12–15 years) were divided into test (302children) and control (293 children) groups. The test group used the dentifrice containing sodiummonofluorophosphate (1000 ppm) and calcium glycerophosphate, whereas the control group wasgiven a placebo dentifrice. Oral examination for dental caries and plaque assessment was carriedout at the start of the study and the children were followed up semiannually up to 18 months. Datawere analyzed using repeated-measure analysis of variance (ANOVA) followed by one-way ANOVA.Results: The values for decayed missing filled teeth (DMFT) increased from baseline to 18 monthexamination from 4.43±2.03 and 4.67±2.25 (P=0.175) to 5.84±2.29 and 5.13±2.30 (P=0.001) forcontrol and test groups, respectively. Similarly, the increase in decayed missing filled surface (DMFS)values were from 6.42±4.10 and 7.06±4.77 (P=0.082) to 8.64±4.51 and 7.92±5.07 (P=0.095) fortest and control groups, respectively. The mean DMFT and DMFS values increased for both thegroups; however, the increase was less in test group as compared to control group. The baselineplaque score reduced from 2.94±0.72 and 2.91±0.72 (P=0.679), respectively, for control and testgroups to 1.33±0.46 and 0.91±0.38 (P<0.001), respectively, at 18 month examination.Conclusion: Results revealed that the test dentifrice was effective in inhibiting the progression ofplaque and control of dental caries as compared to the placebo dentifrice.Key Words: Dentifrice, sodium monofluorophosphate, calcium glycerophosphate