Isfahan University of Medical SciencesDental Research Journal1735-33279120120218Effect of plasma-rich in platelet-derived growth factors on periimplant bone healing: An experimental study in canines902902ENRezaBirangAlirezaTorabiMohammadShahabooeiDepartment of Periodontics and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. shahabooei@dnt.mui.ac.irMansourRismanchian20120218Background: Tissue engineering principles can be exploited to enhance alveolar and peri-implantbone reconstruction by applying such biological factors as platelet-derived growth factors. Theobjective of the present study is to investigate the effect of autologous plasma-rich in growthfactors (on the healing of peri-implant bone in canine mandible).Materials and Methods: In this prospective experimental animal study, two healthy canines ofthe Iranian mix breed were selected. Three months after removing their premolar teeth on bothsides of the mandible, 12 implants of the Osteo Implant Corporationsystem, 5 mm in diameterand 10 mm in length, were selected to be implanted. Plasma rich in growth factors (PRGF) wereapplied on six implants while the other six were used as plain implants without the plasma. Theimplants were installed in osteotomy sites on both sides of the mandible to be removed after 4weeks with the surrounding bones using a trephine bur. Mesio-distal sections and implant blocks,50 μ in diameter containing the peri-implant bone, were prepared By basic fuchin toluidine-blueforhistological and histomorphometric evaluation by optical microscope. The data were analyzed usingMann-Whitney Test (P<0.05).Results: The bone trabeculae and the type of bone generation in PRGF and control groups hadno statistically significant differences (P=0.261, P=0.2) although the parameters showed highermeasured values in the PRGF group. However, compared to the control, application of PRGF hadsignificantly increased bone-to-implant contact (P=0.028)Conclusion: Based on the results, it may be concluded that application of PRGF on the surfaceof implant may enhance bone-to-implant contact.Key Words: Bone-to-implant contact, histological, histomorphometric, platelet-rich plasmagrowth factor