The antioxidant master glutathione and periodontal health

Abstract

Glutathione, considered to be the master antioxidant (AO), is the most-important redox regulator that controls in

Therapeutic considerations for the adjunctive use of glutathione in management of periodontitis, in limiting the tissue damage associated with oxidative stress, and enhancing wound healing cannot beunderestimated, but need to be evaluated further through multi-centered randomized controlled trials.

flammatory processes, and thus damage to the periodontium. Periodontitis patients have reduced total AO capacity in whole saliva, and lower concentrations of reduced glutathione (GSH) in serum and gingival crevicular fluid, and periodontal therapy restores the redox balance.Key Words:Antioxidants, gingival crevicular fluids, glutathione, periodontitis, saliva