Clinical evaluation of the effect of platelet rich plasma on the coronally advanced fl ap root coverage procedure

Abstract

Background: Coronally advanced fl ap (CAF) has been shown to effectively treat gingival recession.

Platelet rich plasma (PRP), containing autologous growth factors, has been shown to promote soft

tissue healing. The aim of this clinical study was to determine whether the addition of an autologous

PRP to a CAF when compared to a CAF alone would improve the clinical outcome for treatment

of multiple gingival recessions.

Materials and Methods: Thirty patients with Miller’s class I and class II buccal recession defect were

randomly assigned to control (CAF alone) or test (CAF with PRP) groups. Recession depth (RD),

recession width (RW), probing depth (PD), clinical attachment level (CAL), width of keratinized tissue,

wound healing index, percentage of root coverage was assessed. Patients were followed at 2, 4, 12

and 16 weeks post-surgery. Statistical analysis for intra and inter group comparisons was done using

Wilcoxon sign rank and Wilcoxon rank sum tests respectively. P < 0.05 denoted statistical signifi cance.

Results: The differences between the test and control groups were not signifi cant with respect

to all the clinical variables. The RD at 16 weeks was signifi cantly reduced from 2.88 ± 0.69 to

0.76 ± 0.24 mm in control group (P < 0.05) and from 2.95 ± 0.43 to 0.76 ± 0.35 mm in the test

group (P < 0.05). The mean percentage of root coverage was 73.1 ± 7.3 in the control group and

75.0 ± 8.3 in test group (P < 0.05). The CAL gain was 3.17 ± 0.84 mm within the control group

and 3.17 ± 0.79 mm within test group.

Conclusion: Within the limitations of this study, PRP with CAF can provide an early healing of

soft tissues, but does not provide clinically measurable improvement in the fi nal therapeutics

outcome in CAF.

Key Words: Gingival recessions, platelet rich plasma, guided tissue regeneration, periodontal