A randomized control trial comparing the efficacy of 3Mixtatin and Modified 3Mix‑MP paste using lesion sterilization and tissue repair technique to conventional root canal treatment in primary molars of children aged 4–8 years: An in vivo study

Seema Thakur, Aman Deep, Parul Singhal, Deepak Chauhan


Background: The aim of this study was to evaluate clinical and radiographic success rates of
3Mixtatin and Modified 3Mix‑MP paste and compare it with conventional root canal treatment
procedure in primary molars requiring pulpectomy.
Materials and Methods: In this in vivo study, 66 primary molars in 52 children aged between 4
and 8 years with primary molars having chronic periapical abscess were treated randomly with
3Mixtatin, Modified 3Mix‑MP paste, and Metapex. The subjects were reviewed at 6 and 12 months
both clinically and radiographically after pulpal therapy to evaluate and compare the healing process.
The data obtained were subjected to statistical analysis at a significance level of 0.05.
Results: By the end of 12‑month follow‑up among the three groups, Group I seemed to be
performing consistently better as compared to the other two groups when evaluated clinically and
radiographically. However, Group III resulted in the greatest number of failures, with success rate
being mere 42.9% at the end of follow‑up period.
Conclusion: Radiographic and clinical healing occurred in all the three groups; however, based
on our results, Group I seemed to be performing consistently better among the three groups at
12‑month follow‑up. Hence, it can be inferred that 3Mixtatin used as a localized agent is effective
and comparable to both Modified 3Mix‑MP paste and conventional pulpectomy procedure involving
calcium hydroxide and iodoform paste in primary teeth.
Key Words: Metapex, primary teeth, pulpectomy

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