Antimicrobial efficacy of antiplaque agents of common toothpastes against Porphyromonas gingivalis and Streptococcus oralis: An in vitro study

Abstract

Background: This study was designed to evaluate the antimicrobial activity of common gum
protection and antiplaque toothpastes against Porphyromonas gingivalis (P. gingivalis) and Streptococcus
oralis (S. oralis) as important periodontal pathogens.
Materials and Methods: This experimental study investigated the antimicrobial activity of 15
commonly used toothpastes from different companies on the two common types of periopathogens,
S. oralis and P. gingivalis. The antimicrobial activity of toothpaste was evaluated at three concentrations
of 100%, 50%, and 25% and analyzed by agar well diffusion plate method and zone of inhibition. The
obtained data were compared and statistically analyzed by SPSS software using one‑way ANOVA
and the least significant difference post hoc tests (α = 0.05).
Results: One‑way ANOVA showed that the mean diameter of the two‑bacterial zone of inhibition
was significantly different at 100%, 50%, and 25% concentrations of toothpastes (P < 0.001). In
general, the mean diameter of the zone of inhibition was greater at 100% concentration than the
other two concentrations in all toothpastes. The highest zone of inhibition of the S. oralis was in
the toothpastes containing tin. Further, the highest zone of inhibition of P. gingivalis was found in
the triclosan‑containing toothpastes.
Conclusion: Toothpastes containing triclosan had the most antimicrobial activity against P. gingivalis.
Moreover, toothpastes containing tin compounds had the most antimicrobial effect against S. oralis.
Key Words: Bacteria, periodontal diseases, toothpastes

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 Narges Naghsh: Pubmed,Google Scholar