The effect of bromelain–acetaminophen combination on the intensity of endodontic postoperative pain: A randomized clinical trial

Abstract

Background: Despite significant advances in dentistry, postendodontic pain is one of the problems
that patients still suffer from. This study aimed to evaluate the effect of bromelain–acetaminophen
combination on the reduction of postendodontic pain in teeth with symptomatic irreversible pulpitis.
Materials and Methods: In this randomized double‑blind clinical trial, 60 patients with mandibular
first molars with irreversible pulpitis were evaluated. To homogenize the samples, patients who
needed endodontic treatment of mandibular first molars with moderate severity were selected
according to the American Association of Endodontists case difficulty assessment form. After
endodontic treatment, half of the patients were given a placebo and 500 mg acetaminophen every
6 h, and the other half were given 500 mg Anahil capsule and 500 mg acetaminophen every 6 h until
the patients’ pain was ameliorated. If the patient did not feel pain, they didn’t take medication, also
we excluded the patients who felt pain for more than 2 days. The Visual Analog Scale (VAS) was used
to measure pain before and 6, 12, 24, and 48 h after endodontic treatment. Data were analyzed by
SPSS (version 22) software using t‑test, Mann–Whitney, and Kaplan–Meyer tests at a 5% error level.
Results: The amount of pain decreased more in the experimental group than in the placebo
group 6 and 12 h after endodontic treatment, but by controlling the effect of initial pain (P = 0.627),
no significant difference was observed between the two groups in the amount of pain (P = 0.875).
Conclusion: The bromelain–acetaminophen combination did not have an added value when it
comes to controlling postendodontic pain.
Key Words: Acetaminophen, bromelain, endodontic treatment, pain

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Ali Ghazalgoo: Pubmed,Google Scholar