Revolutionizing dental restorations: Insights into computer‑aided design/computer‑aided manufacturing materials – A systematic review

Abstract

The integration of computer‑aided design (CAD) and computer‑aided manufacturing (CAM)
technology has significantly transformed restorative dentistry. This review explores the game‑changing
influence of CAD/CAM systems in restorative dentistry, emphasizing the clinical performance,
mechanical attributes, and esthetic potential of contemporary materials such as zirconia, lithium
disilicate, polyetheretherketone, polymethylmethacrylate, and advanced resin composites.This
systematic review, conducted in accordance with Preferred Reporting Items for Systematic Reviews
and Meta‑Analyses guidelines and structured using the PICO framework, comprehensively explored
evidence on CAD/CAM dental materials. A thorough search of PubMed, Scopus, Cochrane Library,
Web of Science, and Google Scholar (2015–2025) initially identified 1300 records. After rigorous
screening and eligibility assessment, studies addressing clinical indications, mechanical performance,
and material‑specific outcomes of CAD/CAM restorations were included for qualitative synthesis.
Lithium disilicate and zirconia emerged as frontrunners in fracture resistance, marginal adaptation,
and long‑term esthetics. Glass‑ceramics and nanohybrid composites demonstrated high performance
in posterior and veneer applications. Comparative trials favored CAD/CAM over conventional
restorations in precision, fit, and durability. Risk‑of‑bias assessment indicated predominantly low bias
across key domains, ensuring reliability of findings. CAD/CAM materials combine digital precision
with clinical excellence, offering strong mechanical performance and refined esthetics for optimal
functional outcomes. Clinical evidence highlights their accuracy, efficiency, and long‑term success
compared to traditional restorative techniques.
Key Words: Computer‑aided design/computer‑aided manufacturing, lithium disilicate, polyetheretherketone, polymethylmethacrylate, resin, zirconia

Highlight

 B. K. Ramnarayan: Pubmed,Google Scholar