Histopathological comparison of the effect of 5% melatonin gel and 1.2% rosuvastatin gel on bone regeneration in the rat model

Abstract

Background: This study aimed to histopathologically compare the efficacy of 5% melatonin (MEL)
gel and 1.2% rosuvastatin (RSV) gel on bone regeneration in rat calvarial defects.
Materials and Methods: In this animal study, 8‑mm defects were created in the calvaria of 24
adult male Wistar rats weighing 200 g. The rats were randomly assigned to three groups (n = 8).
The defects were filled with placebo gel (methylcellulose with no active ingredient) in Group I,
5% MEL gel in Group II, and 1.2% RSV gel in Group III. The rats were sacrificed after 4 weeks.
Hematoxylin and eosin (H and E) staining was used to prepare histological sections. Statistical
analysis was performed using the ANOVA and Tukey tests (α =0.05).
Results: Osteogenesis was significantly higher in the MEL and RSV groups than in the
control group (P < 0.05). However, the difference between the MEL and RSV groups was not
significant (P > 0.05).
Conclusion: Osteogenesis was significantly higher in the MEL and RSV groups than in the control
group (P < 0.05). Local administration of MEL and RSV can be used as a stimulant of bone formation.
However, more investigations are required to evaluate the bone regeneration capacity of MEL and
RSV gels.
Key Words: Bone regeneration, histopathology, melatonin, rats, rosuvastatin

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 Negin Rahimi: Pubmed,Google Scholar