Effect of atorvastatin gel on clinical parameters and bone histology in alveolar ridge preservation: A randomized clinical trial

Abstract

Background: The aim of the study was to evaluate the dimensional changes of the alveolar ridge
in postextraction sockets filled with 1.2% atorvastatin (ATV) gel covered with a collagen membrane.
Materials and Methods: This study is a split‑mouth randomized clinical trial. A total of 30
postextraction sockets of single‑root teeth of 15 patients were randomly allocated into two groups:
(a) socket filling with 1.2% ATV gel and covered with an absorbable collagen membrane (n = 15)
and (b) socket covered with a collagen membrane (n = 15). Four clinical indices – the width and
height of sockets and the width and thickness of keratinized gingiva – were measured at baseline and
2 months after the intervention. Two histological parameters, namely the percentage of osteogenesis
and the thickness of bone trabeculae, were also measured 2 months after the intervention. Data
were analyzed by Mann–Whitney and Wilcoxon tests using SPSS software (P ≤ 0.05).
Results: Two months after extraction, dimensional changes in height (P = 0.07), width of the alveolar
socket (P = 0.381), and keratinized gingival thickness (P = 1) showed no significant difference between
the two groups. In both the groups, the keratinized gingival width increased significantly, but there
was no significant difference between the two groups (P = 0.347). The percentage of lamellar bone
formation in the test group was about 28% higher than that of the control group (P = 0.098), and
the thickness of trabeculae in both the groups was similar (P = 0.78).
Conclusion: Although 1.2% ATV gel increased lamellar bone formation and reduced dimensional
changes in postextraction sockets, the differences were not significant compared with the control
group.
Key Words: Alveolar ridge augmentation, atorvastatin, osteogenesis, tooth socket

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 Parichehr Behfarnia: Pubmed,Google Scholar